The Water-Soil-Waste (W-S-W) Nexus provides a framework for the main factors in food production. This framework, which facilitates the assessment of how policies and activities influence agricultural productivity, is important for all levels of the agricultural industry. It facilitates the assessment of issues that deal with water, soil and waste in a balanced way with full consideration of their impact on the long-term sustainability of the agricultural system and its productivity. This paper explores the linkages between water, soil, and waste in the context of climate and climate change in order to clarify needs for scientific information and observational data. Climate affects water availability, soil integrity and the production and movement of waste material. As the climate changes, its influences on the W-S-W Nexus will also change and new strategies for coping with climate change will therefore be necessary. This paper describes the types of information needed to select and support these new strategies and reviews the current availability of this information. The paper recommends a more comprehensive study of the effects of climate change on the W-S-W Nexus and an evaluation of the current observational systems and datasets to assess changes in W-S-W variables. The paper also encourages responsible agencies to ensure that their data systems are modernized, their data collection programmes for soil and waste data are enhanced, and their data products and knowledge are made freely available to the world’s science community.