Landlocked developing countries (LLDCs) are disadvantaged in a myriad of ways and they have special needs which require special attention. Challenges such as undiversified economies, vulnerability to climate change and climate variability, land degradation and desertification, among others, are undermining the economic potential of many LLDCs. This has been exacerbated by weak export base of many LLDCs centered on a few primary agricultural and/ or mineral commodities. Further, because of their physical location markedly characterized by lack of access to sea ports, LLDCs are popularly referred to as “prisoners of geography”. This study seeks to identify LLDCs’ priority areas on climate change, land degradation and desertification that could be included in their new development agenda. In order to achieve this objective, the study: (a) provides a comprehensive review of the impact of climate change, desertification and land degradation on LLDCs, (b) reviews national, regional and international interventions which have been implemented in LLDCs; (c) identifies best practices, lessons learnt and emerging opportunities and (d) proffers recommendations for inclusion in a new development agenda for LLDCs which will assist them to ameliorate the negative impacts of climate change, desertification and land degradation.