This article summarizes the changes in landscape structure because of human land management over the last several centuries, and using observed and modeled data, documents how these changes have altered biogeophysical and biogeochemical surface fluxes on the local, mesoscale, and regional scales. Remaining research issues are presented including whether these landscape changes alter large-scale atmospheric circulation patterns far from where the land use and land cover changes occur. We conclude that existing climate assessments have not yet adequately factored in this climate forcing. For those regions that have undergone intensive human landscape change, or would undergo intensive change in the future, we conclude that the failure to factor in this forcing risks a misalignment of investment in climate mitigation and adaptation.