The study investigated youth employment challenge and rural transformation in Sub-Saharan Africa. The study employed panel data analysis for 54 independent African countries from 2010 to 2017. The results suggest that youth employment (rural and urban) to population ratio, 15+ , has a great positive influence on rural transformation in African countries. However, results also suggest that an increase in unemployed rural population has an inverse effect on rural transformation. The result shows that youth literacy rate has an inverse relationship with youth unemployment rate. More so, the results also suggest that an increase in employment in the agricultural sector (given the employment in other sectors) would lead to a decline in youth unemployment rate in Africa. However, the evidence also shows that an increase in rural population would aggravate the youth unemployment rate in Africa. The chapter concludes that empowering the youth (through actions to facilitate youth skills development and matching rural youth to jobs; facilitate rural youth access to land; improve access to affordable finance by rural youth; promote MSME development; support social protection and safety net programs; and access to social services) is developing Africa through rural transformation. This may come quickly if youth employment becomes the litmus test of Africa’s development policies.