To achieve the ambitious goals of alleviating poverty, securing food and water supplies, and protecting the natural resource base, we need to recognize the inter-connectedness of the factors driving land degradation, so that solutions can be taken to scale, transforming management practices for millions of land users. An analysis of the critical barriers and incentives to achieve scaling up suggests that the most appropriate options should be selected through the involvement of stakeholders at all levels, from local to national and international.